Analysis of lung air from patients with bronchogenic carcinoma and controls using gas chromatography-mass spectrometry

J Chromatogr. 1988 Nov 18:432:1-11. doi: 10.1016/s0378-4347(00)80627-1.


Volatile metabolites present in expired lung air were collected by odor sampling techniques and analyzed by gas chromatography-mass spectrometry. The study population included controls matched for age and smoking history with patients newly diagnosed with lung carcinoma. Significantly greater concentrations of o-toluidine were found in the lung air of patients with lung carcinoma than either age-matched or younger controls. Aniline was present in half of the patient population but absent in age-matched controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aging / metabolism
  • Air / analysis*
  • Aniline Compounds
  • Carcinoma, Bronchogenic / analysis*
  • Female
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Lung / analysis*
  • Lung Neoplasms / analysis*
  • Male
  • Middle Aged
  • Tolonium Chloride


  • Aniline Compounds
  • Tolonium Chloride