Can chlorine dioxide prevent the spreading of coronavirus or other viral infections? Medical hypotheses

Physiol Int. 2020 Mar 1;107(1):1-11. doi: 10.1556/2060.2020.00015. Epub 2020 Mar 1.


Motivation: Viruses have caused many epidemics throughout human history. The novel coronavirus [10] is just the latest example. A new viral outbreak can be unpredictable, and development of specific defense tools and countermeasures against the new virus remains time-consuming even in today's era of modern medical science and technology. In the lack of effective and specific medication or vaccination, it would be desirable to have a nonspecific protocol or substance to render the virus inactive, a substance/protocol, which could be applied whenever a new viral outbreak occurs. This is especially important in cases when the emerging new virus is as infectious as SARS-CoV-2 [4].

Aims and structure of the present communication: In this editorial, we propose to consider the possibility of developing and implementing antiviral protocols by applying high purity aqueous chlorine dioxide (ClO2) solutions. The aim of this proposal is to initiate research that could lead to the introduction of practical and effective antiviral protocols. To this end, we first discuss some important properties of the ClO2 molecule, which make it an advantageous antiviral agent, then some earlier results of ClO2 gas application against viruses will be reviewed. Finally, we hypothesize on methods to control the spread of viral infections using aqueous ClO2 solutions.

Publication types

  • Editorial

MeSH terms

  • Antiviral Agents / pharmacology
  • Betacoronavirus* / drug effects
  • Betacoronavirus* / pathogenicity
  • Betacoronavirus* / physiology
  • COVID-19
  • Chlorine Compounds / pharmacology*
  • Clinical Protocols
  • Communicable Diseases, Emerging* / prevention & control
  • Communicable Diseases, Emerging* / virology
  • Coronavirus Infections* / epidemiology
  • Coronavirus Infections* / prevention & control
  • Coronavirus Infections* / transmission
  • Coronavirus Infections* / virology
  • Disease Transmission, Infectious / prevention & control*
  • Disinfectants / pharmacology
  • Humans
  • Oxides / pharmacology*
  • Pandemics* / prevention & control
  • Pharmaceutical Solutions / pharmacology
  • Pneumonia, Viral* / epidemiology
  • Pneumonia, Viral* / prevention & control
  • Pneumonia, Viral* / transmission
  • Pneumonia, Viral* / virology
  • Research Design
  • SARS-CoV-2


  • Antiviral Agents
  • Chlorine Compounds
  • Disinfectants
  • Oxides
  • Pharmaceutical Solutions
  • chlorine dioxide