Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

Euro Surveill. 2020 Mar;25(11):2000266. doi: 10.2807/1560-7917.ES.2020.25.11.2000266.

Abstract

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

Keywords: COVID-19; SARS-CoV-2; antibodies; coronavirus; humoral immunity; immunofluorescence assay; microneutralisation test; western blotting; whole-genome sequencing.

MeSH terms

  • Adult
  • Antibodies, Viral / blood
  • Asymptomatic Infections
  • Betacoronavirus
  • China
  • Clinical Laboratory Techniques
  • Contact Tracing*
  • Coronavirus / genetics*
  • Coronavirus / immunology
  • Coronavirus / isolation & purification*
  • Coronavirus Infections* / diagnosis
  • Coronavirus Infections* / transmission
  • Coronavirus Infections* / virology
  • Female
  • Finland
  • Fluorescent Antibody Technique
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Neutralization Tests
  • Pandemics*
  • Pneumonia, Viral* / diagnosis
  • Pneumonia, Viral* / transmission
  • Pneumonia, Viral* / virology
  • SARS Virus / immunology*
  • SARS Virus / pathogenicity
  • Severe Acute Respiratory Syndrome / etiology
  • Severe Acute Respiratory Syndrome / immunology*
  • Severe Acute Respiratory Syndrome / virology
  • Travel*
  • Viral Envelope Proteins

Substances

  • Antibodies, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Viral Envelope Proteins

Supplementary concepts

  • COVID-19
  • COVID-19 diagnostic testing
  • severe acute respiratory syndrome coronavirus 2