Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar 7;2020:6040525.
doi: 10.1155/2020/6040525. eCollection 2020.

Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients

Free PMC article

Apolipoprotein E Gene Polymorphism, Glycated Hemoglobin, and Peripheral Arterial Disease Risk in Chinese Type 2 Diabetic Patients

Yujing Hu et al. Dis Markers. .
Free PMC article


Background: The apolipoprotein E (ApoE) gene polymorphism has been found to influence plasma lipid concentration, and its correlation with peripheral arterial disease (PAD) has been investigated. However, it is unclear whether ApoE is associated with PAD in Chinese type 2 diabetes mellitus (T2DM) patients. Therefore, our study is aimed at investigating the relationship between the ApoE gene polymorphism and PAD in Chinese T2DM patients.

Methods: A total of 192 T2DM patients were divided into two groups: T2DM and T2DM with PAD. The clinical and biochemical parameters were obtained. Polymerase chain reaction was used to identify the genotypes of ApoE. The multivariable logistic regression analysis was used to identify the possible risk factor for PAD.

Results: There were no significant differences in the genotype and allele frequencies of ApoE between the T2DM and T2DM with PAD groups. However, the T2DM with PAD group tended to have more ε4/ε4/.

Conclusions: These results demonstrated that there was no evidence of a relationship between ApoE and PAD.

Conflict of interest statement

The authors declare that they have no competing interests.

Similar articles

See all similar articles


    1. Jude E. B., Eleftheriadou I., Tentolouris N. Peripheral arterial disease in diabetes-a review. Diabetic Medicine. 2010;27(1):4–14. doi: 10.1111/j.1464-5491.2009.02866.x. - DOI - PubMed
    1. Hamburg N. M., Creager M. A. Pathophysiology of intermittent claudication in peripheral artery disease. Circulation Journal. 2017;81(3):281–289. doi: 10.1253/circj.cj-16-1286. - DOI - PubMed
    1. Ankle Brachial Index Collaboration, Fowkes F. G., Murray G. D., et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. Jama. 2008;300:197–208. - PMC - PubMed
    1. Bhatt D. L., Steg P. G., Ohman E. M., et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA. 2006;295(2):180–189. doi: 10.1001/jama.295.2.180. - DOI - PubMed
    1. Vos T., Allen C., Arora M., et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1545–1602. doi: 10.1016/S0140-6736(16)31678-6. - DOI - PMC - PubMed

LinkOut - more resources