Risk factors for non-closure of an intended temporary defunctioning stoma after emergency resection of left-sided obstructive colon cancer

Int J Colorectal Dis. 2020 Jun;35(6):1087-1093. doi: 10.1007/s00384-020-03559-1. Epub 2020 Mar 24.


Purpose: A substantial part (21-35%) of defunctioning stomas created during resection for colorectal cancer will never be reversed. Known risk factors for non-closure are age, peri- or postoperative complications, comorbidity, and tumor stage. However, studies performed to identify these risk factors mostly focus on rectal cancer and include both preoperative and postoperative factors. This study aims to identify preoperative risk factors for non-reversal of intended temporary stomas created during acute resection of left-sided obstructive colon cancer (LSOCC) with primary anastomosis.

Methods: All patients who underwent emergency resection for LSOCC with primary anastomosis and a defunctioning stoma between 2009 and 2016 were selected from the Dutch ColoRectal Audit, and additional data were collected in the local centers. Multivariable analysis was performed to identify independent preoperative factors for non-closure of the stoma.

Results: A total of 155 patients underwent acute resection for LSOCC with primary anastomosis and a defunctioning stoma. Of these, 51 patients (32.9%) did not have their stoma reversed after a median of 53 (range 7-104) months of follow-up. In multivariable analysis, hemoglobin < 7.5 mmol/L (odds ratio (OR) 4.79, 95% confidence interval (95% CI) 1.60-14.38, p = 0.005), estimated glomerular filtration rate (eGFR) ≤ 45 mL/min/1.73 m2 (OR 4.64, 95% CI 1.41-15.10, p = 0.011), and metastatic disease (OR 6.12, 95% CI 2.35-15.94, p < 0.001) revealed to be independent predictors of non-closure.

Conclusions: Anemia, impaired renal function, and metastatic disease at presentation were found to be independent predictors for non-reversal of intended temporary stomas in patients who underwent acute resection for LSOCC. In patients who have an increased risk of non-reversal, the surgeon should consider a Hartmann's procedure.

Keywords: Colorectal cancer; Defunctioning stoma; Non-closure; Obstructive colon cancer; Stoma reversal; Surgical oncology.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anastomosis, Surgical
  • Anemia / blood
  • Colectomy
  • Colon / surgery*
  • Colon, Descending / surgery
  • Colon, Sigmoid / surgery
  • Colonic Neoplasms / complications
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / surgery*
  • Colostomy*
  • Emergencies
  • Female
  • Glomerular Filtration Rate
  • Hemoglobins / metabolism
  • Humans
  • Ileostomy*
  • Ileum / surgery*
  • Intestinal Obstruction / etiology
  • Intestinal Obstruction / surgery*
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Preoperative Period
  • Renal Insufficiency / physiopathology
  • Retrospective Studies
  • Risk Factors


  • Hemoglobins