Dynamic Augmentation of Left Ventricle and Mitral Valve Function With an Implantable Soft Robotic Device

Mossab Y Saeed; David Van Story; Christopher J Payne; Isaac Wamala; Borami Shin; Daniel Bautista-Salinas; David Zurakowski; Pedro J Del Nido; Conor J Walsh; Nikolay V Vasilyev

doi:10.1016/j.jacbts.2019.12.001

Dynamic Augmentation of Left Ventricle and Mitral Valve Function With an Implantable Soft Robotic Device

JACC Basic Transl Sci. 2020 Feb 26;5(3):229-242. doi: 10.1016/j.jacbts.2019.12.001. eCollection 2020 Mar.

Authors

Mossab Y Saeed¹, David Van Story¹, Christopher J Payne^{1

2

3}, Isaac Wamala¹, Borami Shin¹, Daniel Bautista-Salinas^{1

4}, David Zurakowski⁵, Pedro J Del Nido¹, Conor J Walsh^{2

3}, Nikolay V Vasilyev¹

Affiliations

¹ Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
² Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts.
³ John A. Paulson Harvard School of Engineering and Applied Sciences, Harvard University, Boston, Massachusetts.
⁴ School of Industrial Engineering, Technical University of Cartagena, Cartagena, Spain.
⁵ Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Abstract

Left ventricular failure is strongly associated with secondary mitral valve regurgitation. Implantable soft robotic devices are an emerging technology that enables augmentation of a native function of a target tissue. We demonstrate the ability of a novel soft robotic ventricular assist device to dynamically augment left ventricular contraction, provide native pulsatile flow, simultaneously reshape the mitral valve apparatus, and eliminate the associated regurgitation in an Short-term large animal model of acute left ventricular systolic dysfunction.

Keywords: FS, fractional shortening; HF, heart failure; IQR, interquartile range; IVS, interventricular septum; LHF, left heart failure; LV, left ventricular; LVEDP, left ventricular end-diastolic pressure; LVSD, left ventricular systolic dysfunction; MV, mitral valve; MVR, mitral valve regurgitation; RV, right ventricle; SRVAD, soft robotic ventricular assist device; left ventricular systolic dysfunction; mitral valve; secondary mitral regurgitation; soft robotic.