Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

JAMA. 2020 May 12;323(18):1846-1848. doi: 10.1001/jama.2020.4621.

Abstract

This case report describes birth of an infant with elevated anti–SARS-CoV-2 IgM antibodies and cytokine levels to a mother with polymerase chain reaction–confirmed coronavirus disease 2019 (COVID-19) despite no physical contact.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / blood
  • Antibody Specificity
  • Betacoronavirus* / immunology
  • Betacoronavirus* / isolation & purification
  • Cesarean Section / methods
  • Clinical Laboratory Techniques / methods
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / immunology
  • Coronavirus Infections / therapy
  • Coronavirus Infections / transmission*
  • Female
  • Fetal Diseases / virology
  • Humans
  • Immunoglobulin G / blood
  • Immunoglobulin M / blood
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical*
  • Mothers
  • Nasopharynx / virology
  • Pandemics
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / therapy
  • Pneumonia, Viral / transmission*
  • Pregnancy
  • Pregnancy Complications, Infectious* / blood
  • Pregnancy Complications, Infectious* / diagnosis
  • Real-Time Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Time Factors

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • Immunoglobulin M

Supplementary concepts

  • COVID-19
  • COVID-19 diagnostic testing
  • severe acute respiratory syndrome coronavirus 2