Efficacy of 577 nm pro-yellow laser in the treatment of melasma: a prospective split-face study

J Cosmet Laser Ther. 2020 Feb 17;22(2):107-110. doi: 10.1080/14764172.2020.1744661. Epub 2020 Mar 27.


We aimed to study the effectiveness of 577 nm pro-yellow laser in the treatment of melasma. A total of 82 patients with melasma were included in this comparative study. A detailed medical history, examination, and calculation of Melasma Area and Severity Index were done for all patients. All participants were treated with topical sunscreen and hydroquinone 4% cream on both sides of the face. In addition, the left side of the face was subjected to a single pass of 577-nm pro-yellow laser at a monthly interval for three sessions. Follow up was done by comparing the Melasma area and severity index at 0, 3 and 6 months. At baseline, there is no significant difference in the Melasma area and severity index score between both sides of the face. At 3 months, MASI score was statistically significantly decreased on both sides of the face compared to pretreatment (P < .05). At 6 months, the mean MASI score at the laser-treated side was statistically significantly decreased compared to the non-laser-treated side (P < .05). we concluded that the addition of 577 nm pro-yellow laser in the treatment of melasma leads to maintain the improvement and reduction of the recurrence rate.

Keywords: Melasma; hydroquinone cream; pro-yellow laser.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Combined Modality Therapy
  • Female
  • Humans
  • Hydroquinones / administration & dosage
  • Hydroquinones / therapeutic use*
  • Lasers, Solid-State / adverse effects
  • Lasers, Solid-State / therapeutic use*
  • Low-Level Light Therapy / adverse effects
  • Low-Level Light Therapy / methods*
  • Male
  • Melanosis
  • Middle Aged
  • Prospective Studies
  • Severity of Illness Index
  • Sunscreening Agents / administration & dosage
  • Sunscreening Agents / therapeutic use*
  • Young Adult


  • Hydroquinones
  • Sunscreening Agents
  • hydroquinone