Should the Vancomycin Minimal Inhibitory Concentration be used as an Infant Critical Care Regular Criteria?

Curr Pharm Biotechnol. 2020;21(11):1052-1058. doi: 10.2174/1389201021666200327162402.


Background: Vancomycin is the first-line antibiotic used for the treatment of staphylococcal infections. Because of its narrow therapeutic window and the pharmacokinetics variability, vancomycin trough serum concentration should be monitored. However, due to the increased cases of staphylococcus' commensal species infections and the case of vancomycin resistance, the minimal inhibitory concentration should be considered on antimicrobial therapy.

Objective: This article aimed to show the importance of the minimal inhibitory concentration to infants on vancomycin therapy as regular criteria.

Materials and methods: Three infants in the use of vancomycin, hospitalized in the same maternity hospital, and that had at least one blood culture performed during the intensive-care-unit hospitalization were included in the study. Vancomycin serum concentrations were determined by particleenhanced- turbidimetric inhibition-immunoassay. The vancomycin minimal inhibitory concentration data were interpreted by following the Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST). The trough serum concentration range of 10 to 20 mg.L-1 was considered therapeutic.

Results: All three patients had at least one infection by S. epidermidis, being one patient exhibit vancomycin- resistant S. epidermidis infection. All patients had stoppages in the vancomycin treatment, and the minimal inhibitory concentration was performed for only one patient.

Conclusion: The data obtained from these patients also showed the need to perform therapeutic monitoring by using minimal inhibitory concentration values, because, although the serum concentrations were within the reference range, they are insufficient to guarantee patient therapeutic success.

Keywords: Infants vancomycin therapy; Staphylococcus epidermidis; antibiotic resistance; blood culture; drug monitoring; minimal inhibitory concentration.

MeSH terms

  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / therapeutic use
  • Critical Care / methods*
  • Drug Monitoring / methods*
  • Drug Resistance, Bacterial
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Microbial Sensitivity Tests
  • Staphylococcal Infections / blood
  • Staphylococcal Infections / drug therapy*
  • Staphylococcus epidermidis / drug effects*
  • Staphylococcus epidermidis / isolation & purification
  • Vancomycin / administration & dosage*
  • Vancomycin / blood
  • Vancomycin / therapeutic use


  • Anti-Bacterial Agents
  • Vancomycin