Imaging of Neuronal and Mixed Glioneuronal Tumors

J Comput Assist Tomogr. 2020 May/Jun;44(3):356-369. doi: 10.1097/RCT.0000000000001010.


Neuronal and mixed glioneuronal tumors represent a group of neoplasms with varying degrees of neural and glial elements. Their age of presentation varies, but they are most commonly seen in children and young adults. With the exception of anaplastic ganglioglioma and other atypical variants, most lesions are low grade; however, they can have significant morbidity because of seizures, mass effect, or difficult to treat hydrocephalus. Although many tumors show overlapping clinical and imaging features, some have relatively distinctive imaging characteristics that may aid in narrowing the differential diagnosis. In this review, we discuss relevant clinical and pathologic characteristics of these tumors and provide an overview of conventional and advanced imaging features that provide clues as to the diagnosis.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Child
  • Female
  • Hamartoma Syndrome, Multiple / diagnostic imaging
  • Hamartoma Syndrome, Multiple / pathology
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Neoplasms, Neuroepithelial / diagnostic imaging*
  • Neoplasms, Neuroepithelial / pathology
  • Tomography, X-Ray Computed
  • Young Adult