Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?

Int J Mol Sci. 2020 Mar 25;21(7):2272. doi: 10.3390/ijms21072272.

Abstract

The emergence of the novel coronavirus in Wuhan, China, which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Most coronaviruses infect animals but can evolve into strains that cross the species barrier and infect humans. At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. Immunotherapy with IVIg could be employed to neutralize COVID-19. However, the efficacy of IVIg would be better if the immune IgG antibodies were collected from patients who have recovered from COVID-19 in the same city, or the surrounding area, in order to increase the chance of neutralizing the virus. These immune IgG antibodies will be specific against COVID-19 by boosting the immune response in newly infected patients. Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available.

Keywords: IVIg; coronavirus; immunotherapy; nCoV-2019; virus.

MeSH terms

  • Animals
  • Betacoronavirus / immunology*
  • COVID-19
  • Coronavirus Infections / immunology
  • Coronavirus Infections / therapy*
  • Humans
  • Immune System*
  • Immunization, Passive
  • Immunoglobulins, Intravenous / isolation & purification
  • Immunoglobulins, Intravenous / therapeutic use*
  • Mice
  • Pandemics
  • Periodicals as Topic
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / therapy*
  • SARS-CoV-2

Substances

  • Immunoglobulins, Intravenous

Supplementary concepts

  • COVID-19 serotherapy