Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;20(5):559-564.
doi: 10.1016/S1473-3099(20)30176-6. Epub 2020 Mar 24.

Clinical Features and Obstetric and Neonatal Outcomes of Pregnant Patients With COVID-19 in Wuhan, China: A Retrospective, Single-Centre, Descriptive Study

Free PMC article

Clinical Features and Obstetric and Neonatal Outcomes of Pregnant Patients With COVID-19 in Wuhan, China: A Retrospective, Single-Centre, Descriptive Study

Nan Yu et al. Lancet Infect Dis. .
Free PMC article


Background: In December, 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China. The number of affected pregnant women is increasing, but scarce information is available about the clinical features of COVID-19 in pregnancy. This study aimed to clarify the clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19.

Methods: In this retrospective, single-centre study, we included all pregnant women with COVID-19 who were admitted to Tongji Hospital in Wuhan, China. Clinical features, treatments, and maternal and fetal outcomes were assessed.

Findings: Seven patients, admitted to Tongji Hospital from Jan 1, to Feb 8, 2020, were included in our study. The mean age of the patients was 32 years (range 29-34 years) and the mean gestational age was 39 weeks plus 1 day (range 37 weeks to 41 weeks plus 2 days). Clinical manifestations were fever (six [86%] patients), cough (one [14%] patient), shortness of breath (one [14%] patient), and diarrhoea (one [14%] patient). All the patients had caesarean section within 3 days of clinical presentation with an average gestational age of 39 weeks plus 2 days. The final date of follow-up was Feb 12, 2020. The outcomes of the pregnant women and neonates were good. Three neonates were tested for SARS-CoV-2 and one neonate was infected with SARS-CoV-2 36 h after birth.

Interpretation: The maternal, fetal, and neonatal outcomes of patients who were infected in late pregnancy appeared very good, and these outcomes were achieved with intensive, active management that might be the best practice in the absence of more robust data. The clinical characteristics of these patients with COVID-19 during pregnancy were similar to those of non-pregnant adults with COVID-19 that have been reported in the literature.

Funding: National Natural Science Foundation of China, Hubei Provincial Natural Science Foundation of China.


Chest CT of four patients Patient 1 (A), patient 3 (B), patient 4 (C), and patient 6 (D). The brightness of both lungs is diffusely decreased, showing a large area of multiple ground-glass opacities or patchy shadow with an uneven density.

Comment in

Similar articles

See all similar articles

Cited by 6 articles

See all "Cited by" articles


    1. Lu H, Stratton CW, Tang Y-W. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020 doi: 10.1002/jmv.25678. published online Jan 16. - DOI
    1. Hui DSI, Azhar EI, Madani TA. The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis. 2020;91:264–266. - PMC - PubMed
    1. Huang C, Wang Y, Li X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. - PMC - PubMed
    1. WHO Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance. Jan 28, 2020.
    1. WHO Novel coronavirus—China. Jan 12, 2020.

Publication types

Supplementary concepts