A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

Cell. 2020 Apr 16;181(2):223-227. doi: 10.1016/j.cell.2020.03.035. Epub 2020 Mar 26.

Abstract

The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins.

MeSH terms

  • Animals
  • Animals, Wild
  • Betacoronavirus / genetics*
  • COVID-19
  • China
  • Chiroptera / virology*
  • Coronavirus Infections / transmission
  • Coronavirus Infections / virology*
  • Disease Reservoirs / virology*
  • Environmental DNA
  • Genome, Viral
  • Pandemics
  • Pneumonia, Viral / transmission
  • Pneumonia, Viral / virology*
  • SARS-CoV-2
  • Sequence Analysis, RNA
  • Zoonoses / virology

Substances

  • Environmental DNA