Curing HIV: Seeking to Target and Clear Persistent Infection

Cell. 2020 Apr 2;181(1):189-206. doi: 10.1016/j.cell.2020.03.005. Epub 2020 Mar 26.


Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic infection, approaches to eradicate or cure HIV infection are desired. Attempts to augment ART with therapies that reverse viral latency, paired with immunotherapies to clear infection, have advanced into the clinic, but the field is still in its infancy. We review foundational studies and highlight new insights in HIV cure research. Together with advances in ART delivery and HIV prevention strategies, future therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Anti-HIV Agents / therapeutic use*
  • Chronic Disease / therapy*
  • HIV Infections / therapy*
  • HIV-1 / drug effects*
  • Haplorhini
  • Humans
  • Immunotherapy / methods*
  • Virus Latency / drug effects*


  • Anti-HIV Agents