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. 2020 Mar 27;10(1):5600.
doi: 10.1038/s41598-020-62595-7.

The Association of Pregnancy-induced Hypertension With Bronchopulmonary Dysplasia - A Retrospective Study Based on the Korean Neonatal Network Database

Free PMC article

The Association of Pregnancy-induced Hypertension With Bronchopulmonary Dysplasia - A Retrospective Study Based on the Korean Neonatal Network Database

Seung Hyun Shin et al. Sci Rep. .
Free PMC article


The prevalence of pregnancy-induced hypertension (PIH) and preeclampsia (PE) are 5-10% and 2-4%, respectively. PIH might affect angiogenesis in preterm neonates, but its association with bronchopulmonary dysplasia (BPD) remains controversial. This study evaluated the association between PIH and BPD in very low-birth weight infants. We retrospectively analysed the maternal, perinatal, and neonatal data of preterm infants born before 30 weeks of gestation, selected from the nationwide registry of very low-birth weight infants, between January 2013 and December 2014. As a result, 1,624 infants without maternal PIH (gestational age: 27.3 ± 1.8 weeks) and 203 infants with maternal PIH (28.0 ± 1.4 weeks, p < 0.001) were included. Birth weight was higher in the non-PIH group, compared with the PIH group (1027.4 ± 250.2 vs. 876.4 ± 261.5 g, p < 0.001). Multivariate logistic regression showed that PIH was associated with BPD (adjusted OR 1.474, 95% confidence interval 1.025-2.121), after adjusting for confounders, including small-for-gestation age (SGA). The result of present study is consistent with the current concept of BPD as an early form of pulmonary vascular disease, for both PIH and BPD are attributed by abnormal vascular formation.

Conflict of interest statement

The authors declare no competing interests.


Figure 1
Figure 1
Flow chart of the study population. Among 3,507 infants registered, 2,276 infants who were born at less than 30 weeks of gestation were enrolled and 1,827 were analysed. BPD: bronchopulmonary dysplasia, GA: gestational age, HTN: hypertension, KNN: Korean Neonatal Network, PIH: pregnancy-induced hypertension, PMA: postmenstrual age.

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