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Review
. 2020 Mar 27.
doi: 10.1007/s13238-020-00707-9. Online ahead of print.

Memory T Cells: Strategies for Optimizing Tumor Immunotherapy

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Review

Memory T Cells: Strategies for Optimizing Tumor Immunotherapy

Qingjun Liu et al. Protein Cell. .

Abstract

Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understanding of the mechanisms underlying the differentiation of effector and memory T cells is of increasing importance for developing immunological strategies against various tumors. This review focuses on recent advances in efficacy against tumors, the origin, formation mechanisms of memory T cells, and the role of the gut microbiota in memory T cell formation. Furthermore, we summarize strategies to generate memory T cells in (ex) vivo that, might be applicable in clinical practice.

Keywords: gut microbiota; memory T cells; metabolism; tumor immunology.

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