Development of a DNA Adductome Mass Spectral Database

Jingshu Guo; Robert J Turesky; Anamary Tarifa; Anthony P DeCaprio; Marcus S Cooke; Scott J Walmsley; Peter W Villalta

doi:10.1021/acs.chemrestox.0c00031

Development of a DNA Adductome Mass Spectral Database

Chem Res Toxicol. 2020 Apr 20;33(4):852-854. doi: 10.1021/acs.chemrestox.0c00031. Epub 2020 Mar 30.

Authors

Jingshu Guo^{1

2}, Robert J Turesky^{1

2}, Anamary Tarifa³, Anthony P DeCaprio³, Marcus S Cooke⁴, Scott J Walmsley^{1

5}, Peter W Villalta^{1

2}

Affiliations

¹ Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States.
² Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.
³ Forensic & Analytical Toxicology Facility, Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
⁴ Oxidative Stress Group, Department of Environmental Health Sciences, Florida International University, Miami, Florida 33199, United States.
⁵ Institute of Health Informatics, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Abstract

Mass spectrometry-based DNA adductomics is an emerging approach for the human biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be created for the scientific community to investigate the associations between chemical exposures, DNA damage, and disease risk.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

DNA Adducts / drug effects*
DNA Damage
Databases, Chemical*
Environmental Pollutants / chemistry
Environmental Pollutants / pharmacology*
Humans
Mass Spectrometry
Organic Chemicals / chemistry
Organic Chemicals / pharmacology*

Substances

DNA Adducts
Environmental Pollutants
Organic Chemicals

Abstract

Publication types

MeSH terms

Substances

Grants and funding