Cardamonin: A new player to fight cancer via multiple cancer signaling pathways

Life Sci. 2020 Jun 1;250:117591. doi: 10.1016/j.lfs.2020.117591. Epub 2020 Mar 26.

Abstract

Nature's pharmacy has undoubtedly served humans as an affordable and safer health-care regime for a long times. Cardamonin, a chalconoid present in several plants has been known for a longtime to have beneficial properties towards human health. In this review, we aimed to highlight the recent advances achieved in discovering the pharmacological properties of cardamonin. Cardamonin is cardamom-derived chalcone, which plays a role in cancer treatment, immune system modulation, inflammation and pathogens killing. Through the modulation of cellular signaling pathways, cardamonin activates cell death signal to induce apoptosis in malignant cells that results in the inhibition of cancer development. Moreover, cardamonin arrests cell cycle by altering the expression of regulatory proteins during malignant cells division. Due to its relatively selective cytotoxic potential against host malignant cells, cardamonin is emerging as a promising novel experimental anticancer agent. The potential of cardamonin to target various signaling molecules, transcriptional factors, cytokines and enzymes, such as mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2 enhances the opportunity to explore it as a new multi-target therapeutic agent. The pharmacokinetic and biosafety profile of cardamonin favor it as a potentially safe biomolecule for pharmaceutical drug development.

Keywords: Anticancer; Cardamom; Cardamonin; Chalcone.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Apoptosis
  • Cell Cycle
  • Cell Line, Tumor
  • Chalcones / pharmacology*
  • Humans
  • Immune System
  • Inflammation
  • Liver / drug effects
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Neovascularization, Pathologic
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction*

Substances

  • Antineoplastic Agents, Phytogenic
  • Chalcones
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • cardamonin