Cerium oxide nanoparticles: A promising tool for the treatment of fibrosarcoma in-vivo

Esmail Nourmohammadi; Hoda Khoshdel-Sarkarizi; Reza Nedaeinia; Majid Darroudi; Reza Kazemi Oskuee

doi:10.1016/j.msec.2019.110533

Cerium oxide nanoparticles: A promising tool for the treatment of fibrosarcoma in-vivo

Mater Sci Eng C Mater Biol Appl. 2020 Apr:109:110533. doi: 10.1016/j.msec.2019.110533. Epub 2019 Dec 6.

Authors

Esmail Nourmohammadi¹, Hoda Khoshdel-Sarkarizi², Reza Nedaeinia³, Majid Darroudi⁴, Reza Kazemi Oskuee⁵

Affiliations

¹ Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Research Center of Advanced Technology in Medicine, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
² Department of Anatomical Sciences and Cell Biology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: darroudim@mums.ac.ir.
⁵ Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: Oskueekr@mums.ac.ir.

PMID: 32229006
DOI: 10.1016/j.msec.2019.110533

Abstract

In this study, we used cerium oxide nanoparticles and evaluated their anti-cancer effects in a mouse model of fibrosarcoma. For evaluation of anti-cancer effects of nanoceria, tumor volume measurement, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, quantitative real-time PCR (qPCR) for Bax and Bcl2 genes, a panel of liver and kidney function tests and hematoxylin-eosin staining were done. Nanoceria dominantly accumulated in the tumor and it could significantly decrease tumor growth and volume in tumor-bearing mice that received nanoceria for four weeks. Cerium oxide nanoparticle showed potential anti-cancer properties against fibrosarcoma.

Keywords: Bax; Bcl2; Cerium oxide nanoparticles; Fibrosarcoma; TUNEL.

MeSH terms

Animals
Cell Line, Tumor
Cerium* / chemistry
Cerium* / pharmacology
Female
Fibrosarcoma / drug therapy*
Fibrosarcoma / metabolism
Fibrosarcoma / pathology
Mice
Mice, Inbred BALB C
Nanoparticles* / chemistry
Nanoparticles* / therapeutic use
Neoplasms, Experimental / drug therapy*
Neoplasms, Experimental / metabolism

Substances

Cerium
ceric oxide