NUCB2/nesfatin-1 - Inhibitory effects on food intake, body weight and metabolism

Martha A Schalla; Suraj Unniappan; Nils W G Lambrecht; Masatomo Mori; Yvette Taché; Andreas Stengel

doi:10.1016/j.peptides.2020.170308

NUCB2/nesfatin-1 - Inhibitory effects on food intake, body weight and metabolism

Peptides. 2020 Jun:128:170308. doi: 10.1016/j.peptides.2020.170308. Epub 2020 Mar 27.

Authors

Martha A Schalla¹, Suraj Unniappan², Nils W G Lambrecht³, Masatomo Mori⁴, Yvette Taché⁵, Andreas Stengel⁶

Affiliations

¹ Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.
² Laboratory of Integrative Neuroendocrinology, Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
³ Department of Pathology and Laboratory Medicine, VA Medical Center, Long Beach, California, USA.
⁴ Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan.
⁵ VA Greater Los Angeles Healthcare System, Los Angeles, California, USA; Department of Medicine, CURE: Digestive Diseases Research Center, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.
⁶ Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany. Electronic address: andreas.stengel@med.uni-tuebingen.de.

PMID: 32229144
DOI: 10.1016/j.peptides.2020.170308

Abstract

Since its discovery in 2006 by Oh-I and colleagues, NUCB2/nesfatin-1 encoded by nucleobindin-2 (NUCB2) has drawn sustained attention as reflected in over 500 publications. Among those, more than half focused on the alterations of food intake, body weight and metabolism (glucose, fat) induced by nesfatin-1 and/or NUCB2/nesfatin-1. In the current review we discuss the existing literature focusing on NUCB2/nesfatin-1's influence on food intake, body weight and glucose as well as fat metabolism and highlight gaps in knowledge.

Keywords: Anorexigenic; Blood glucose; Body weight; Fat; Food intake; Gut-brain axis; Hypothalamus; Insulin; Obesity; Satiety.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Body Weight / drug effects*
Eating / drug effects*
Fats / metabolism
Glucose / metabolism
Humans
Hypothalamus / drug effects
Hypothalamus / metabolism
Nucleobindins / metabolism*
Nucleobindins / pharmacology*

Substances

Fats
NUCB2 protein, human
Nucb2 protein, mouse
Nucb2 protein, rat
Nucleobindins
Glucose

Grants and funding

CIHR/Canada