Virology, Epidemiology, Pathogenesis, and Control of COVID-19

Viruses. 2020 Mar 27;12(4):372. doi: 10.3390/v12040372.

Abstract

The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. To provide a comprehensive summary to public health authorities and potential readers worldwide, we detail the present understanding of COVID-19 and introduce the current state of development of measures in this review.

Keywords: COVID-19; SARS-CoV-2; epidemiology; pathogenesis; therapeutics.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Betacoronavirus
  • China
  • Clinical Laboratory Techniques / methods*
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / physiopathology*
  • Coronavirus Infections / prevention & control*
  • Coronavirus Infections / therapy*
  • Genome, Viral
  • Humans
  • Pandemics / prevention & control*
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / physiopathology*
  • Pneumonia, Viral / prevention & control*
  • Pneumonia, Viral / therapy*
  • Public Health
  • Viral Vaccines

Substances

  • Antiviral Agents
  • COVID-19 vaccine
  • Viral Vaccines

Supplementary concepts

  • COVID-19
  • COVID-19 diagnostic testing
  • severe acute respiratory syndrome coronavirus 2