Electroencephalographic read-outs of the modulation of cortical network activity by deep brain stimulation

Astrid Kibleur; Olivier David

doi:10.1186/s42234-018-0003-x

Electroencephalographic read-outs of the modulation of cortical network activity by deep brain stimulation

Bioelectron Med. 2018 Mar 15:4:2. doi: 10.1186/s42234-018-0003-x. eCollection 2018.

Authors

Astrid Kibleur^{1

2}, Olivier David^{1

2

3}

Affiliations

¹ University Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, 38000 Grenoble, France.
² 2Inserm, U1216, 38000 Grenoble, France.
³ 3Grenoble Institut des Neurosciences - Chemin Fortuné Ferrini - Bât EJ Safra, 38700 La Tronche, France.

Abstract

Deep brain stimulation (DBS), a reversible and adjustable treatment for neurological and psychiatric refractory disorders, consists in delivering electrical currents to neuronal populations located in subcortical structures. The targets of DBS are spatially restricted, but connect to many parts of the brain, including the cortex, which might explain the observed clinical benefits in terms of symptomatology. The DBS mechanisms of action at a large scale are however poorly understood, which has motivated several groups to recently conduct many research programs to monitor cortical responses to DBS. Here we review the knowledge gathered from the use of electroencephalography (EEG) in patients treated by DBS. We first focus on the methodology to record and process EEG signals concurrently to DBS. In the second part of the review, we address the clinical and scientific benefits brought by EEG/DBS studies so far.

Keywords: Cortical networks; Deep brain stimulation; Electroencephalography; Functional neuroanatomy; Signal processing.

Publication types

Review