Association of Nijmegen Breakage Syndrome 1 Genotypes With Bladder Cancer Risk

Abstract

Background/aim: We aimed to examine the association of the genotypes of Nijmegen breakage syndrome 1 (NBS1), a critical gene in DNA double strand break repair machinery, with bladder cancer risk in Taiwan.

Materials and methods: NBS1 rs1805794 genotypes among 375 bladder cancer patients and 375 non-cancer healthy controls were determined via the polymerase chain reaction-restriction fragment length polymorphism methodology and their association with bladder cancer risk were evaluated.

Results: The results showed that the percentages of GG, CG and CC of NBS1 rs1805794 genotypes were 45.4%, 43.7% and 10.9% in the bladder cancer patient group and 47.2%, 43.2% and 9.6% in the non-cancer control group, respectively (p for trend=0.7873). The analysis of allelic frequency distributions showed that the variant C allele of NBS1 rs1805794 does not contribute to an increased bladder cancer susceptibility (p=0.5066).

Conclusion: The genotypes of NBS1 rs1805794 are not closely associated with personal susceptibility to bladder cancer.

Keywords: Bladder cancer; NBS1; case–control study; genotype; polymorphism.