Methods: These bulletins are not systematic reviews and do not involve critical appraisal or include a detailed summary of study findings. Rather, they present an overview of the technology and available evidence. They are not intended to provide recommendations for or against a technology.
Literature Search Strategy: A limited literature search was conducted by an information specialist on key resources including MEDLINE, Embase, PubMed, the Cochrane Library, the University of York Centre for Reviews and Dissemination databases, the websites of Canadian and major international health technology agencies, as well as a focused Internet search. The search strategy was comprised of both controlled vocabulary, such as the National Library of Medicine’s MeSH (Medical Subject Headings) and keywords. The main search concepts were inclisiran and hyperlipidemia. No filters were applied to limit the retrieval by study type. Where possible, retrieval was limited to the human population. The search was also limited to English language documents published between January 1, 2014 and June 7, 2019. Internet links were provided, where available. Alerts were run until September 2019.
Study Selection: One author screened the literature search results and reviewed the full text of all potentially relevant studies. Studies were considered for inclusion if the intervention was inclisiran and hyperlipidemia. Conference abstracts and grey literature were included when they provided additional information to that available in the published studies.
Peer Review: A draft version of this bulletin was reviewed by one clinical expert.
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