Coronavirus disease 2019 (COVID-19): a clinical update

Front Med. 2020 Apr;14(2):126-135. doi: 10.1007/s11684-020-0767-8. Epub 2020 Apr 2.


Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

Keywords: clinical characteristics; coronavirus disease 2019; epidemiology; pathology; radiology; treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Antiviral Agents / therapeutic use
  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections* / complications
  • Coronavirus Infections* / diagnostic imaging
  • Coronavirus Infections* / epidemiology
  • Coronavirus Infections* / therapy
  • Humans
  • Immunization, Passive
  • Pandemics*
  • Pneumonia, Viral* / complications
  • Pneumonia, Viral* / diagnostic imaging
  • Pneumonia, Viral* / epidemiology
  • Pneumonia, Viral* / therapy
  • SARS-CoV-2
  • Stroke / drug therapy
  • Stroke / etiology
  • Tomography, X-Ray Computed


  • Antiviral Agents

Supplementary concepts

  • COVID-19 serotherapy