Nervous system involvement after infection with COVID-19 and other coronaviruses

Brain Behav Immun. 2020 Jul;87:18-22. doi: 10.1016/j.bbi.2020.03.031. Epub 2020 Mar 30.

Abstract

Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties and may also cause neurological diseases. It is reported that CoV can be found in the brain or cerebrospinal fluid. The pathobiology of these neuroinvasive viruses is still incompletely known, and it is therefore important to explore the impact of CoV infections on the nervous system. Here, we review the research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system.

Keywords: COVID-19; Coronaviruses infection; Mechanisms; Nervous system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Betacoronavirus
  • Consciousness Disorders / etiology
  • Consciousness Disorders / physiopathology
  • Coronavirus 229E, Human
  • Coronavirus Infections / complications
  • Coronavirus Infections / physiopathology*
  • Coronavirus NL63, Human
  • Coronavirus OC43, Human
  • Dysgeusia / etiology
  • Dysgeusia / physiopathology
  • Encephalitis / etiology
  • Encephalitis / physiopathology
  • Encephalitis, Viral / etiology
  • Encephalitis, Viral / physiopathology
  • Guillain-Barre Syndrome / etiology
  • Guillain-Barre Syndrome / physiopathology
  • Humans
  • Middle East Respiratory Syndrome Coronavirus
  • Nervous System Diseases / etiology
  • Nervous System Diseases / physiopathology*
  • Neurotoxicity Syndromes / etiology
  • Neurotoxicity Syndromes / physiopathology
  • Neurotoxicity Syndromes / virology
  • Olfaction Disorders / etiology
  • Olfaction Disorders / physiopathology
  • Pandemics
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / physiopathology*
  • Polyneuropathies / etiology
  • Polyneuropathies / physiopathology
  • SARS Virus
  • Seizures / etiology
  • Seizures / physiopathology
  • Severe Acute Respiratory Syndrome / complications
  • Severe Acute Respiratory Syndrome / physiopathology
  • Stroke / etiology
  • Stroke / physiopathology

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2