Since the discovery of fibroblast growth factor (FGF) in the early 20th century, the multiple regulatory function of FGF has been found in development, metabolic regulation and tissue regeneration. Although FGF has the potential in wound healing of clinical practice, several technical bottlenecks occurred in the development of FGF drugs. Since 1992, our team has had many technical breakthroughs and developed some class Ⅰ new drugs of FGF and medical device. At the same time, we further investigated the network of metabolic regulation and signal transduction of FGF. All the efforts were for the purpose of the development of FGF new drugs and bringing benefit to patients.
自20世纪初发现成纤维细胞生长因子(FGF)后，研究发现其在发育、代谢调控和组织再生等方面均发挥着重要作用。FGF治疗可成为创面修复重要的疗法之一，然而在其成药过程中却遭遇了重大技术瓶颈。自1992年开始，笔者团队不断突破FGF成药技术瓶颈，成功开发多个一类新药及医疗器械。与此同时还深入研究FGF的代谢调控网络及信号转导机制，努力开发FGF新药，造福广大患者。.
Keywords: Fibroblast growth factors; Metabolic regulation; Wound repair.