Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence

Exp Biol Med (Maywood). 2020 Apr;245(8):733-739. doi: 10.1177/1535370220916888. Epub 2020 Apr 2.


The present study combined the analysis of two transcriptional regulators, uVNTR and dVNTR, in the MAOA gene that is an enzyme responsible for the monoamine degradation and identified genetic interaction between these VNTRs in association with the nicotine dependence. The main impact is that when analyzing different populations in the genetic studies, the functionally meaningful variants should be combined rather than addressing individual elements separately (a mini polygenic risk score for a particular gene/locus). This combination is very rarely analyzed and therefore the study sets an example. Another impact is that we analyzed the genetic variability in the Asian population and therefore our data present a piece of information from underrepresented populations.

Keywords: Fagerström Test for Nicotine Dependence; MAOA; Variable number tandem repeat; Vietnam; genetic interaction; nicotine dependence; smoking; stratification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Male
  • Microsatellite Repeats*
  • Monoamine Oxidase / genetics*
  • Polymorphism, Genetic*
  • Tobacco Smoking / genetics*
  • Tobacco Use Disorder / genetics*


  • Monoamine Oxidase
  • monoamine oxidase A, human