Endocrine and metabolic link to coronavirus infection

Nat Rev Endocrinol. 2020 Jun;16(6):297-298. doi: 10.1038/s41574-020-0353-9.

Abstract

Type 2 diabetes mellitus and hypertension are the most common comorbidities in patients with coronavirus infections. Emerging evidence demonstrates an important direct metabolic and endocrine mechanistic link to the viral disease process. Clinicians need to ensure early and thorough metabolic control for all patients affected by COVID-19.

MeSH terms

  • Aldosterone / physiology
  • Betacoronavirus / physiology*
  • Comorbidity
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / etiology*
  • Coronavirus Infections / metabolism
  • Coronavirus Infections / physiopathology
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetes Mellitus, Type 2 / virology
  • Endocrine System / physiology*
  • Endocrine System / physiopathology
  • Energy Metabolism / physiology*
  • Host-Pathogen Interactions / physiology*
  • Humans
  • Inflammation / complications
  • Inflammation / metabolism
  • Inflammation / physiopathology
  • Inflammation / virology
  • Pandemics
  • Peptidyl-Dipeptidase A / physiology
  • Pneumonia, Viral / epidemiology
  • Pneumonia, Viral / etiology*
  • Pneumonia, Viral / metabolism
  • Pneumonia, Viral / physiopathology
  • Renin-Angiotensin System / physiology
  • Risk Factors
  • Signal Transduction / physiology

Substances

  • Aldosterone
  • ACE protein, human
  • Peptidyl-Dipeptidase A

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2