Mechano-genomic regulation of coronaviruses and its interplay with ageing

Nat Rev Mol Cell Biol. 2020 May;21(5):247-248. doi: 10.1038/s41580-020-0242-z.

Abstract

Coronaviruses employ various nuclear signalling mechanisms for their propagation. Here we link replication of coronaviruses, including SARS-CoV-2, the coronavirus disease 2019 (COVID-19)-causing virus, with cytoskeleton-dependent signalling and 3D genome organization. This link could provide novel insights into the high coronavirus pathogenicity in certain cellular states, particularly those associated with ageing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Betacoronavirus / pathogenicity
  • Betacoronavirus / physiology*
  • COVID-19
  • Coronavirus Infections / pathology
  • Cytoskeleton / metabolism
  • Cytoskeleton / virology*
  • Genome, Viral
  • Host-Pathogen Interactions / physiology*
  • Humans
  • NF-kappa B / metabolism
  • Pandemics
  • Pneumonia, Viral / pathology
  • SARS-CoV-2
  • Signal Transduction
  • Virus Replication / physiology

Substances

  • NF-kappa B