Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr 3;10.1002/jmv.25822.
doi: 10.1002/jmv.25822. Online ahead of print.

Imaging and Clinical Features of Patients With 2019 Novel Coronavirus SARS-CoV-2: A Systematic Review and Meta-Analysis

Affiliations
Free PMC article
Review

Imaging and Clinical Features of Patients With 2019 Novel Coronavirus SARS-CoV-2: A Systematic Review and Meta-Analysis

Yinghao Cao et al. J Med Virol. .
Free PMC article

Abstract

Background: Currently, the epidemic of coronavirus disease 2019 (COVID-19) has begun to spread worldwide. We aim to explore reliable evidence for the diagnosis and treatment of the COVID-19 by analyzing all the published studies by Chinese scholars on the clinical and imaging features in novel coronavirus pneumonia caused by SARS-CoV-2.

Methods: We searched five medical databases including two Chinese and three English databases for all published articles on COVID-19 since the outbreak. A random-effects model was designed, and the imaging and clinical data from all studies were collected for meta-analysis.

Results: Overall, 31 articles and 46 959 patients were included, including 10 English articles and 21 Chinese articles. The results of meta-analysis showed that the most common clinical manifestations were fever (87.3%; 0.838-0.909), cough (58.1%; 0.502-0.660), dyspnea (38.3%; 0.246-0.520), muscle soreness or fatigue (35.5%; 0.253-0.456), and chest distress (31.2%; -0.024 to 0.648). The main imaging findings were bilateral pneumonia (75.7%; 0.639-0.871) and ground-glass opacification (69.9%; 0.602-0.796). Among the patients, the incidence that required intensive care unit (ICU) was (29.3%; 0.190-0.395), the incidence with acute respiratory distress syndrome was (28.8%; 0.147-0.429), the incidence with multiple organ dysfunction syndrome was (8.5%; -0.008 to 0.179), and the case fatality rate of patients with COVID-19 was (6.8%; 0.044-0.093).

Conclusion: COVID-19 is a new clinical infectious disease that mainly causes bilateral pneumonia and lung function deteriorates rapidly. Nearly a third of patients need to be admitted to the ICU, and patients are likely to present respiratory failure or even death.

Keywords: 2019 novel coronavirus pneumonia; SARS-CoV-2; clinical features; imaging finding.

Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Diagram of documents retrieval
Figure 2
Figure 2
The forest plots of age and sex. A, age and (B) sex
Figure 3
Figure 3
The forest plots of the incidence of comorbidities and intensive care unit (ICU). A, Comorbidities; (B) tumor; (C) diabetes; (D) hypertension; (E) cardiovascular disease; (F) phthisis; (G) chronic obstructive pulmonary disease; (H) chronic hepatonephropathy; (I) ICU
Figure 4
Figure 4
The forest plots of the incidence of clinical features. A, Fever; (B) cough; (C) sore throat; (D) expectoration; (E) chest distress; (F) muscle soreness or fatigue; (G) headache; (H) diarrhea; (I) dyspnea
Figure 5
Figure 5
The forest plots of the incidence of laboratory test features. A, Leukocytosis; (B) leukopenia; (C) lymphocytopenia; (D) high C‐reactive protein; (E) high lactate dehydrogenase; (F) high erythrocyte sedimentation rate
Figure 6
Figure 6
The forest plots of the incidence of imaging features. A, Unilateral; (B) bilateral; (C) lung consolidation; (D) ground‐glass; (E) air bronchogram; (F) grid‐form shadow; (G) bronchovascular bundles thickening; (H) hydrothorax; (I) irregular or halo sign
Figure 7
Figure 7
The forest plots of the incidence of complication. A, acute respiratory distress syndrome; (B) acute cardiac injury; (C) acute renal injury; (D) shock; (E) multiple organ dysfunction syndrome; (F) mortality

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci. 2020;63(3):457‐460. - PMC - PubMed
    1. Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus‐infected pneumonia. N Engl J Med. 2020;382(13):1199‐1207. - PMC - PubMed
    1. Zhou P, Yang X, Wang X, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270‐273. - PMC - PubMed
    1. Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID‐19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420‐422. - PMC - PubMed
    1. Institute of Health Economics . Quality Appraisal of Case Series Studies Checklist; 2014.
Feedback