Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation

Cell Stem Cell. 2020 Apr 2;26(4):473-475. doi: 10.1016/j.stem.2020.03.001.


Asymmetric partitioning of damaged proteins is thought to play a key role in preserving stem cell function with age. In this issue of Cell Stem Cell, Morrow et al. (2020) show that vimentin recruits proteasome machinery to aggresomes to control NSC proteostasis during quiescence exit.

Publication types

  • Comment

MeSH terms

  • Humans
  • Neural Stem Cells* / metabolism
  • Prisoners*
  • Proteasome Endopeptidase Complex / metabolism
  • Proteolysis
  • Vimentin


  • Vimentin
  • Proteasome Endopeptidase Complex