Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation

Sun Y Maybury-Lewis; Ashley E Webb

doi:10.1016/j.stem.2020.03.001

Taking Prisoners: Vimentin Cages Capture Proteasomes during NSC Activation

Cell Stem Cell. 2020 Apr 2;26(4):473-475. doi: 10.1016/j.stem.2020.03.001.

Authors

Sun Y Maybury-Lewis¹, Ashley E Webb²

Affiliations

¹ Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
² Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA. Electronic address: ashley_webb@brown.edu.

PMID: 32243805
DOI: 10.1016/j.stem.2020.03.001

Abstract

Asymmetric partitioning of damaged proteins is thought to play a key role in preserving stem cell function with age. In this issue of Cell Stem Cell, Morrow et al. (2020) show that vimentin recruits proteasome machinery to aggresomes to control NSC proteostasis during quiescence exit.

Publication types

Comment

MeSH terms

Humans
Neural Stem Cells* / metabolism
Prisoners*
Proteasome Endopeptidase Complex / metabolism
Proteolysis
Vimentin

Substances

Vimentin
Proteasome Endopeptidase Complex