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. 2020 Apr 2;78(1):9-29.
doi: 10.1016/j.molcel.2020.03.011.

How RNA-Binding Proteins Interact With RNA: Molecules and Mechanisms

Free PMC article

How RNA-Binding Proteins Interact With RNA: Molecules and Mechanisms

Meredith Corley et al. Mol Cell. .
Free PMC article


RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse. In this review, we take a look at the components of protein-RNA interaction, from the molecular level to multi-component interaction. We first summarize what is known about protein-RNA molecular interactions based on analyses of solved structures. We additionally describe software currently available for predicting protein-RNA interaction and other resources useful for the study of RBPs. We then review the structure and function of seventeen known RNA-binding domains and analyze the hydrogen bonds adopted by protein-RNA structures on a domain-by-domain basis. We conclude with a summary of the higher-level mechanisms that regulate protein-RNA interactions.

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Conflict of interest statement

Declaration of Interests G.W.Y. is co-founder, member of the board of directors, equity holder, and paid consultant for Locana and Eclipse BioInnovations. G.W.Y. is a Distinguished Visiting Professor at the National University of Singapore. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. All other authors declare no competing interests.

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