Ceftizoxime concentrations in human aqueous humor following intravenous administration

Chemioterapia. 1988 Oct;7(5):317-9.


The aqueous humor penetration of the third-generation cephalosporin, ceftizoxime, was determined in 21 patients awaiting cataract extraction, after an intravenous bolus injection of 2 g. The beta-lactam compound achieved a mean peak aqueous humor concentration of 7.8 mg/l two hours after administration with a serum/humor percent ratio ranging between 7 and 16% during the four-hour sampling interval. Therefore, ceftizoxime levels in this extravascular fluid were above the minimum inhibitory concentrations for the majority of sensitive organisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aqueous Humor / metabolism*
  • Ceftizoxime / administration & dosage
  • Ceftizoxime / blood
  • Ceftizoxime / pharmacokinetics*
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged


  • Ceftizoxime