Lewy body disease with and without dementia: a clinicopathological study of 35 cases

Clin Neuropathol. 1988 Nov-Dec;7(6):299-305.


The pathological basis for dementia in Lewy body disease (LBD) remains controversial. While some investigators propose that cortical lesions are responsible, others favor a subcortical basis for this dementia. Brains from 35 patients with LBD (11 demented with diffuse LBD; 12 demented and 12 non-demented with a brainstem type of LBD) were clinicopathologically examined to elucidate the pathological differences between demented and non-demented patients with LBD. In cases of diffuse LBD, the cortical lesions were found to be responsible for the dementia. In some of the cases (25%) with the brainstem type of LBD, the dementia was attributed to an Alzheimer pathology, while in many cases (75%), degeneration in the subcortical nuclei, mainly the nucleus basalis of Meynert, played a major role in the dementia.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain Diseases / complications
  • Brain Diseases / pathology*
  • Brain Stem / pathology*
  • Cytoplasmic Granules / pathology*
  • Dementia / etiology*
  • Dementia / pathology
  • Female
  • Humans
  • Male
  • Middle Aged