Epidemiology of Hepatic Encephalopathy

Clin Liver Dis. 2020 May;24(2):157-174. doi: 10.1016/j.cld.2020.01.001. Epub 2020 Mar 2.


Hepatic encephalopathy (HE) is a complex condition with multiple causes each with varying degrees of severity. HE negatively impacts patients' quality of life, and it is associated with significant burdens to patients and their caregivers. The prevalence of cirrhosis, the most common risk factor for HE, has steadily increased during recent years. In turn, an upsurge in the clinical and health care burdens related to HE is expected in the upcoming years. This article provides a comprehensive review of the epidemiology of HE.

Keywords: Disease classification; Hepatic encephalopathy; Incidence; Prevalence; Prevention; Risk factors.

Publication types

  • Review

MeSH terms

  • Hepatic Encephalopathy / classification
  • Hepatic Encephalopathy / epidemiology*
  • Hepatic Encephalopathy / etiology*
  • Hepatic Encephalopathy / prevention & control
  • Humans
  • Incidence
  • Liver Cirrhosis / complications
  • Portasystemic Shunt, Transjugular Intrahepatic / adverse effects
  • Prevalence
  • Risk Factors
  • Survival Rate