Breast cancer diagnosis based on lipid profiling by probe electrospray ionization mass spectrometry

Br J Surg. 2020 May;107(6):632-635. doi: 10.1002/bjs.11613. Epub 2020 Apr 4.

Abstract

Probe electrospray ionization mass spectrometry (PESI-MS) is an ambient ionization-based mass spectrometry method that surpasses the original electrospray ionization technique in features such as the rapidity of analysis, simplicity of the equipment and procedure, and lower cost. This study found that the PESI-MS system with machine learning has the potential to establish a lipid-based diagnosis of breast cancer with higher accuracy, using a simpler approach. Rapid mass spectrometry for breast cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / metabolism*
  • Biopsy
  • Breast / metabolism*
  • Breast / pathology
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Case-Control Studies
  • Female
  • Humans
  • Lipid Metabolism*
  • Logistic Models
  • Sensitivity and Specificity
  • Spectrometry, Mass, Electrospray Ionization*

Substances

  • Biomarkers, Tumor