Novel insights into prebiotic properties on human health: A review

Food Res Int. 2020 May:131:108973. doi: 10.1016/j.foodres.2019.108973. Epub 2020 Jan 8.


Dietary prebiotics can be metabolized by different colonic microorganisms and release several classes of metabolites, particularly SCFAs into the intestine lumen, influencing the host physiology. Thus, human microbiota has been the focus of one of the most dynamic research fields of our time and their efforts are directed to understand how prebiotics structures and the microbiota-derived metabolites acts on signaling cell pathways and epigenetic control. Therefore, the aim of this review is to provide an overview about the new concept of prebiotics and their mechanistic local and systemically insights related to the host health.

Keywords: Acetate (PubChem CID: 175); Butyrate (PubChem CID: 104775); Dietary fiber; Epigenetic modifications; Fructooligosaccharides (PubChem CID: 439709); Galactooligosaccharides (PubChem CID: 165512); Inulin (PubChem CID: 24763); Lactate (PubChem CID: 612); Malvidin-3′-O-glucoside (PubChem CID: 443652); Methylated urolithin A (PubChem CID: 27725205); Microbiota; N-3 polyunsaturated fatty acids; N-3 polyunsaturated fatty acids (PubChem CID: 56842239); N-Acetyl chitobiose [(GlcNAc)2] (PubChem CID 10156719); Polyphenols; Prebiotic substrate; Propionate (PubChem CID: 104745); Short-chain fatty acids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diet
  • Gastrointestinal Microbiome / drug effects*
  • Humans
  • Phytochemicals / pharmacology
  • Prebiotics*


  • Phytochemicals
  • Prebiotics