Comparative genomics in infectious disease

Ahmed M Moustafa; Arnav Lal; Paul J Planet

doi:10.1016/j.mib.2020.02.009

Comparative genomics in infectious disease

Curr Opin Microbiol. 2020 Feb:53:61-70. doi: 10.1016/j.mib.2020.02.009. Epub 2020 Apr 2.

Authors

Ahmed M Moustafa¹, Arnav Lal², Paul J Planet³

Affiliations

¹ Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
² School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.
³ Division of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman College of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Sackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA. Electronic address: planetp@email.chop.edu.

Abstract

With more than one million bacterial genome sequences uploaded to public databases in the last 25 years, genomics has become a powerful tool for studying bacterial biology. Here, we review recent approaches that leverage large numbers of whole genome sequences to decipher the spread and pathogenesis of bacterial infectious diseases.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacteria / classification
Bacteria / genetics*
Bacteria / isolation & purification
Bacterial Infections / microbiology*
Communicable Diseases / microbiology*
Genome, Bacterial
Genomics
Humans
Whole Genome Sequencing

Abstract

Publication types

MeSH terms

Grants and funding