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. 2020 Apr 5;1-6.
doi: 10.1080/14786419.2020.1749613. Online ahead of print.

Velucarpin D, a New Pterocarpan From the Stems of Dalbergia velutina and Its Cytotoxicity

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Velucarpin D, a New Pterocarpan From the Stems of Dalbergia velutina and Its Cytotoxicity

Sutin Kaennakam et al. Nat Prod Res. .

Abstract

A new pterocarpan, named velucarpin D (1), along with nine known pterocarpans (2-10) were isolated from the stems of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, Hep G2, and HT-29). Compound 2 showed potent cytotoxicity against all the five human cancer cell lines with IC50 values in the range of 4.74-8.46 µM. In addition, compounds 1, 3, 4, 5 and 9 showed moderate cytotoxicity against both KB and HeLa S-3 cells with IC50 values in the range of 14.23-29.35 µM.

Keywords: Dalbergia velutina; Velucarpin D; cytotoxicity; pterocarpans.

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