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. 2020 Jun;19(6):102536.

doi: 10.1016/j.autrev.2020.102536. Epub 2020 Apr 3.

ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia

Felice Rivellese¹, Edoardo Prediletto²

Affiliations

Affiliations

¹ Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Electronic address: f.rivellese@qmul.ac.uk.
² Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

PMID: 32251718
PMCID: PMC7195011
DOI: 10.1016/j.autrev.2020.102536

Free PMC article

ACE2 at the centre of COVID-19 from paucisymptomatic infections to severe pneumonia

Felice Rivellese et al. Autoimmun Rev. 2020 Jun.

Free PMC article

. 2020 Jun;19(6):102536.

doi: 10.1016/j.autrev.2020.102536. Epub 2020 Apr 3.

Authors

Felice Rivellese¹, Edoardo Prediletto²

Affiliations

¹ Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. Electronic address: f.rivellese@qmul.ac.uk.
² Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

PMID: 32251718
PMCID: PMC7195011
DOI: 10.1016/j.autrev.2020.102536

No abstract available

PubMed Disclaimer

Figures

Fig. 1 — Fig. 1.
Angiotensin system and the development of lung injury in COVID-19. A) steady state in physiological condition; B) excess of angiotensin II signaling via AT2R1 following downregulation of ACE2 because of SARS-CoV-2 infection results in immune cell activation and lung injury. Abbreviations: ACE: Angiotensin convertin enzyme; ACE2: Angiotensin convertin enzyme 2; AT2R1: Angiotensin 2 receptor 1; AT2R2: Antiogensin 2 receptor 2

Fig. 2 — Fig. 2
Possible mechanisms linking ACE2 functional deficit and different responses to SARS-CoV-2 in young vs elderly individuals and/or with coborbidities. Abbreviations: ACE: Angiotensin convertin enzyme; ACE2: Angiotensin convertin enzyme 2; AT2R1: Angiotensin 2 receptor 1; AT2R2: Antiogensin 2 receptor 2; AT2: alveolar type II cells

See this image and copyright information in PMC

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