Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study

C Paula Lewis-de Los Angeles; Paige L Williams; Lisanne M Jenkins; Yanling Huo; Kathleen Malee; Kathryn I Alpert; Kristina A Uban; Megan M Herting; John G Csernansky; Sharon L Nichols; Russell B Van Dyke; Elizabeth R Sowell; Lei Wang; Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study

doi:10.1016/j.nicl.2020.102246

Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study

Neuroimage Clin. 2020:26:102246. doi: 10.1016/j.nicl.2020.102246. Epub 2020 Mar 16.

Authors

Affiliations

¹ Northwestern University Interdepartmental Neuroscience Program, Northwestern University, Chicago, IL, USA.
² Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA, USA; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
³ Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA.
⁴ Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁵ Department of Public Health, University of California Irvine, Irvine, CA, USA.
⁶ Department of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
⁷ Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
⁸ Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.
⁹ Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
¹⁰ Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA; Department of Radiology, Northwestern University, Chicago, IL, USA. Electronic address: leiwang1@northwestern.edu.

Abstract

Youth with perinatally-acquired HIV (PHIV) experience specific and global cognitive deficits at increased rates compared to typically-developing HIV-uninfected youth. In youth with PHIV, HIV infects the brain early in development. Neuroimaging studies have demonstrated altered grey matter morphometry in youth with PHIV compared to typically-developing youth. This study examined cortical thickness, surface area, and gyrification of grey matter in youth (age 11-20 years old) with PHIV (n = 40) from the Pediatric HIV/AIDS Cohort Study (PHACS) compared to typically-developing presumed HIV uninfected and unexposed youth (n = 80) from the Pediatric Imaging, Neurocognition and Genetics Study (PING) using structural magnetic resonance imaging. This study also examined the relationship between grey matter morphometry and age. Youth with PHIV had reduced cortical thickness, surface area, and gyrification compared to typically-developing youth. In addition, an inverse relationship between age and grey matter volume was found in typically-developing youth, but was not observed in youth with PHIV. Longitudinal studies are necessary to understand the neurodevelopmental trajectory of youth with PHIV.

Keywords: Brain; Grey matter; Neurodevelopment; Perinatally-acquired HIV.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adolescent
Brain / pathology*
Child
Cohort Studies
Cross-Sectional Studies
Female
HIV Infections / congenital*
HIV Infections / pathology*
Humans
Magnetic Resonance Imaging
Male
Young Adult

Abstract

Publication types

MeSH terms

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