Association between FCGR2A rs1801274 and MUC5B rs35705950 variations and pneumonia susceptibility

BMC Med Genet. 2020 Apr 6;21(1):71. doi: 10.1186/s12881-020-01005-1.


Background: Herein, we collected currently published data to comprehensively evaluate the impact of the FCGR2A (Fc fragment of IgG receptor IIa) rs1801274 and MUC5B (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on susceptibility to pneumonia diseases.

Methods: We retrieved case-control studies from three online databases and applied the statistical approach of meta-analysis for a series of pooling analyses.

Results: A total of fourteen case-control studies were included for FCGR2A rs1801274; while thirty-one case-control studies were included for MUC5B rs35705950. No significant difference between pneumonia cases and controls for FCGR2A rs1801274 was found. However, MUC5B rs35705950 was significantly associated with pneumonia susceptibility in the whole population under the genetic models of allelic T vs. G [OR (odds ratio) =3.78], carrier T vs. G (OR = 3.31), TT vs. GG (OR = 13.66), GT vs. GG (OR = 4.78), GT + TT vs. GG (OR = 5.05), and TT vs. GG + GT (OR = 6.47) (all P < 0.001, Bonferroni-adjusted P < 0.006; false discovery rate-adjusted P < 0.0010). Furthermore, we observed a similar positive result for subgroup analyses of "Caucasian", "Asian", "population-based control", and "idiopathic pulmonary fibrosis".

Conclusions: MUC5B rs35705950, but not FCGR2A rs1801274, increases susceptibility to clinical pneumonia, especially to idiopathic pulmonary fibrosis, in both the Caucasian and Asian populations.

Keywords: FCGR2A; MUC5B; Pneumonia; Susceptibility; Variation.

Publication types

  • Meta-Analysis

MeSH terms

  • Alleles
  • Asian People / genetics
  • Asian People / statistics & numerical data
  • Case-Control Studies
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Idiopathic Pulmonary Fibrosis / epidemiology
  • Idiopathic Pulmonary Fibrosis / genetics
  • Mucin-5B / genetics*
  • Pneumonia / epidemiology
  • Pneumonia / genetics*
  • Polymorphism, Single Nucleotide*
  • Receptors, IgG / genetics*
  • White People / genetics
  • White People / statistics & numerical data


  • FCGR2A protein, human
  • MUC5B protein, human
  • Mucin-5B
  • Receptors, IgG