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Review
. 2020 Aug;287(15):3141-3149.
doi: 10.1111/febs.15322. Epub 2020 Apr 21.

Resistin in metabolism, inflammation, and disease

Deeksha Tripathi  1 , Sashi Kant  2 , Saurabh Pandey  3 , Nasreen Z Ehtesham  4
Affiliations
Free article
Review

Resistin in metabolism, inflammation, and disease

Deeksha Tripathi et al. FEBS J. 2020 Aug.
Free article

Abstract

Resistin is a small secretory protein that has a pleiotropic role in rodents and humans. Both rodent resistin and human resistin have an extremely stable and high-order multimeric structure. Moreover, there is significant variation in the source of secretion and the diversity of functions of resistin. Mouse resistin resists insulin action and contributes to type 2 diabetes mellitus, while human resistin plays a role in inflammation and also functions as a small accessory chaperone. Currently, active research in the area identified a significant role for resistin in stress biology and as a biomarker in diagnostics to evaluate disease status and treatment outcome. This review summarizes recent developments within resistin biology including their association with obesity, inflammation, stress response mechanisms, and its role in clinical diagnostics.

Keywords: biomarker; diabetes; inflammation; resistin; unfolded protein response.

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