ACE2 the Janus-faced protein - from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19

Clin Sci (Lond). 2020 Apr 17;134(7):747-750. doi: 10.1042/CS20200363.


Angiotensin converting enzyme 2 (ACE2) is the major enzyme responsible for conversion of Ang II into Ang-(1-7). It also acts as the receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which causes Coronavirus Disease (COVID)-19. In recognition of the importance of ACE2 and to celebrate 20 years since its discovery, the journal will publish a focused issue on the basic science and (patho)physiological role of this multifunctional protein.

Keywords: ACE2 receptor; Angiotensin; COVID-19; cardiovascular; coronavirus; hypertension.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin-Converting Enzyme 2
  • Betacoronavirus / physiology
  • COVID-19
  • Cardiovascular Diseases / metabolism
  • Coronavirus Infections / metabolism*
  • Coronavirus Infections / pathology*
  • Humans
  • Pandemics
  • Peptidyl-Dipeptidase A / metabolism*
  • Pneumonia, Viral / metabolism*
  • Pneumonia, Viral / pathology*
  • Renin-Angiotensin System
  • SARS-CoV-2


  • Peptidyl-Dipeptidase A
  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2