Intravenous Laser Wavelength Irradiation Effect on Interleukins: IL-1α, IL-1β, IL6 in Diabetic Rats

Laser Ther. 2019 Dec 31;28(4):267-273. doi: 10.5978/islsm.19-OR-18.


Background and aims: The main purpose of this investigation in Low-Level Laser Therapy (LLLT) on diabetic rats is laser wavelength effect on interleukins: IL-1α, IL-1β, IL6.

Materials subjects and methods: At first, diabetes was induced in Wistar rats by streptozotocin (STZ) injection. Then, by intravenous laser therapy, the rats were irradiated by four continuous wave lasers: IR (λ = 808 nm), Red (λ = 638 nm), Green (λ = 532 nm) and Blue (λ= 450 nm) to compare the related laser wavelength effect on different interleukins. The inflammatory parameters were measured 2,6 and 24 hours after laser therapy from blood samples and plotted for different laser wavelengths.

Results: The results show a decrease in all the above parameters by different laser irradiation in comparison to non-radiated diabetic control ones. More importantly with constant laser energy as the laser wavelength decreases, it affects more efficiently on lowering the above parameters.

Conclusions: we can conclude from our data on diabetic rats that in intravenous LLLT, with constant laser energy, shorter wavelengths like Blue (λ= 450 nm) is more effective than longer wavelengths such as Red (λ = 638 nm) and IR (λ = 808 nm) lasers to lower the level of interleukins toward non-diabetic ones.

Keywords: Diabetesi; IL-1α; IL1-β; IL6; Inflammation; Low Level Laser Therapy.