Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection

J Immunol Res. 2020 Mar 16;2020:2781350. doi: 10.1155/2020/2781350. eCollection 2020.

Abstract

Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.

MeSH terms

  • Adult
  • Aged
  • Antiviral Agents / therapeutic use*
  • Dendritic Cells / immunology*
  • Female
  • Fibrosis
  • Hepacivirus / physiology*
  • Hepatitis C, Chronic / immunology
  • Hepatitis C, Chronic / therapy*
  • Humans
  • Immunity, Innate
  • Immunotherapy / methods*
  • Interferon-alpha / therapeutic use*
  • Liver / pathology*
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Monocytes / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Antiviral Agents
  • Interferon-alpha