Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T1-weighted magnetic resonance imaging applications

Dan Ma; Jingwen Chen; Yu Luo; Han Wang; Xiangyang Shi

doi:10.1039/c7tb01588g

Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T₁-weighted magnetic resonance imaging applications

J Mater Chem B. 2017 Sep 21;5(35):7267-7273. doi: 10.1039/c7tb01588g. Epub 2017 Aug 24.

Authors

Dan Ma¹, Jingwen Chen, Yu Luo, Han Wang, Xiangyang Shi

Affiliation

¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China. xshi@dhu.edu.cn.

PMID: 32264176
DOI: 10.1039/c7tb01588g

Abstract

We report a convenient strategy to prepare ultrasmall Fe₃O₄ nanoparticles (NPs) coated with zwitterion l-cysteine (Cys) for enhanced T₁-weighted magnetic resonance (MR) imaging applications. The formed Fe₃O₄-PEG-Cys NPs possess antifouling properties, good r₁ relaxivity, excellent cytocompatibility and hemocompatibility, and can be used as a contrast agent for enhanced blood pool and tumor MR imaging.