Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes

Blood Adv. 2020 Apr 14;4(7):1378-1382. doi: 10.1182/bloodadvances.2019000853.


  1. Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger.

  2. Clonal expansion of CD8+ effector T lymphocytes can occur following vaccination and accompany graft dysfunction or aplastic anemia relapse.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anemia, Aplastic*
  • CD8-Positive T-Lymphocytes
  • Humans
  • Lymphocytes
  • Recurrence