X Caps the Phosphate for Phospho-Rab GTPase Recognition in Ciliogenesis and Parkinson's Disease

Structure. 2020 Apr 7;28(4):385-387. doi: 10.1016/j.str.2020.03.005.

Abstract

Some Rab GTPases, after activation by GDP to GTP exchange, are phosphorylated by the LRRK2 kinase implicated in Parkinson's disease. In the current issue of Structure, Waschbüsch et al. (2020) investigate the structural basis for recognition of active phospho-Rab GTPases by the RH2 domain of the effector protein RILPL2.

Publication types

  • Comment

MeSH terms

  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Parkinson Disease*
  • Phosphates
  • Phosphorylation
  • rab GTP-Binding Proteins

Substances

  • Phosphates
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • RAB8A protein, human
  • rab GTP-Binding Proteins